STUDIES ON HEGGLIN SYNDROME

Ultrastructural Studies of the May-Hegglin Anomaly

By S. W. JORDAN AND \V. E. LARSEN I HE INHERITED CONDITION known as the May-Hegghin anomaly is characterized by the occurrence of crescent or spindle-shaped cytoplasmic inclusions containing ribose nucleic acid ( RNA ) in polymorphonuclear leukocytes in combination with platelet abnormalities. May ( 1909) 1 noted the presence of distinctive basophilic, pyroninophilic patches in the cytoplasm of...

Ultrastructural Studies of the May-hegglin Anomaly.

The May-Hegglin anomaly: platelet function, ultrastructure and chromosome studies.

T HE MAY-HEGCLIN ANOMALY is a rare hereditary condition characterized by giant platelets and D#{246}hle inclusion bodies in the granulocytes. May first described the anomaly in 1909,’ and in 1945 Hegglin described the condition in a man and his two sons.2 Subsequent reports have confirmed the familial nature with an autosomal dominant mode of inheritance.3 3 Although most persons with the May-H...

Platelet membrane studies in the May-Hegglin anomaly.

Since studies of the giant platelets in the Bernard-Soulier syndrome have shown decreased electrophoretic mobility, decreased sialic acid, and an abnormality in a membrane glycoprotein, we performed similar studies on the giant platelets from two patients with the May-Hegglin anomaly. The patients' platelet electrophoretic mobilities did not differ from control. Although the total sialic acid c...

Studies on Egg Drop Syndrome in Iran